Race, Genetic Ancestry, and Estimating Kidney Function in CKD.

ABSTRACT:

Background

The inclusion of race in equations to estimate the glomerular filtration rate (GFR) has become controversial. Alternative equations that can be used to achieve similar accuracy without the use of race are needed.

Methods

In a large national study involving adults with chronic kidney disease, we conducted cross-sectional analyses of baseline data from 1248 participants for whom data, including the following, had been collected: race as reported by the participant, genetic ancestry markers, and the serum creatinine, serum cystatin C, and 24-hour urinary creatinine levels.

Results

Using current formulations of GFR estimating equations, we found that in participants who identified as Black, a model that omitted race resulted in more underestimation of the GFR (

SUBMITTER: Hsu CY 

PROVIDER: S-EPMC8994696 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature