ProbC: joint modeling of epigenome and transcriptome effects in 3D genome.

ABSTRACT:

Background

Hi-C and its high nucleosome resolution variant Micro-C provide a window into the spatial packing of a genome in 3D within the cell. Even though both techniques do not directly depend on the binding of specific antibodies, previous work has revealed enriched interactions and domain structures around multiple chromatin marks; epigenetic modifications and transcription factor binding sites. However, the joint impact of chromatin marks in Hi-C and Micro-C interactions have not been globally characterized, which limits our understanding of 3D genome characteristics. An emerging question is whether it is possible to deduce 3D genome characteristics and interactions by integrative analysis of multiple chromatin marks and associate interactions to functionality of the interacti

SUBMITTER: Sefer E 

PROVIDER: S-EPMC8994916 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature