Quantitative evaluation of upper limb ataxia in spinocerebellar ataxias.

ABSTRACT:

Objective

To quantitatively evaluate upper limb ataxia using a novel pen-like sensor device in patients with spinocerebellar ataxia (SCA) and to assess its validity, reliability, and sensitivity to disease progression.

Methods

We designed a cross-sectional and longitudinal study of patients with SCA and healthy controls. Upper limb ataxia was evaluated using a device that measures the three-dimensional position every 10 msec. Participants were instructed to move a pen-like part of the device iteratively between two buttons. We evaluated the time, length, velocity, and variation coefficient of the stroke, and calculated the distortion index using the mean squared error. The following scales were also evaluated: Scale for the Assessment and Rating of Ataxia (SARA), the Interna

SUBMITTER: Kishimoto Y 

PROVIDER: S-EPMC8994984 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature