Sonothermogenetics for noninvasive and cell-type specific deep brain neuromodulation.

ABSTRACT:

Background

Critical advances in the investigation of brain functions and treatment of brain disorders are hindered by our inability to selectively target neurons in a noninvasive manner in the deep brain.

Objective

This study aimed to develop sonothermogenetics for noninvasive, deep-penetrating, and cell-type-specific neuromodulation by combining a thermosensitive ion channel TRPV1 with focused ultrasound (FUS)-induced brief, non-noxious thermal effect.

Methods

The sensitivity of TRPV1 to FUS sonication was evaluated in vitro. It was followed by in vivo assessment of sonothermogenetics in the activation of genetically defined neurons in the mouse brain by two-photon calcium imaging. Behavioral response evoked by sonothermogenetic stimulation at a deep brain target was

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8995105 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature