Recurrent pregnancy loss: fewer chromosomal abnormalities in products of conception? a meta-analysis.

ABSTRACT:

Objective

To compare the prevalence of chromosomal abnormalities detected in products of conception (POCs) between recurrent pregnancy loss and sporadic pregnancy loss.

Methods

A systematic search was performed in the PubMed and Embase databases from inception to December 31, 2020. Relevant studies analysing the association between the number of pregnancy losses and the incidence of chromosomal abnormalities were included. Independent data extraction was conducted and study quality was assessed. Meta-analyses were carried out to calculate odds ratios by using fixed- or random-effects models according to statistical homogeneity.

Results

A total of 8320 POCs in 19 studies were identified for the meta-analyses. The incidence of chromosomal abnormalities in sporadic pregn

SUBMITTER: Lei D 

PROVIDER: S-EPMC8995223 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature