Fast myocardial T_1ρ mapping in mice using k-space weighted image contrast and a Bloch simulation-optimized radial sampling pattern.

ABSTRACT:

Purpose

T_1ρ dispersion quantification can potentially be used as a cardiac magnetic resonance index for sensitive detection of myocardial fibrosis without the need of contrast agents. However, dispersion quantification is still a major challenge, because T_1ρ mapping for different spin lock amplitudes is a very time consuming process. This study aims to develop a fast and accurate T_1ρ mapping sequence, which paves the way to cardiac T_1ρ dispersion quantification within the limited measurement time of an in vivo study in small animals.

Methods

A radial spin lock sequence was developed using a Bloch simulation-optimized sampling pattern and a view-sharing method for image reconstruction. For validation, phantom measurements with a con

SUBMITTER: Gram M 

PROVIDER: S-EPMC8995242 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature