Eye-specific quantitative dynamic contrast-enhanced MRI analysis for patients with intraocular masses.

ABSTRACT:

Objective

Dynamic contrast enhanced (DCE)-MRI is currently not generally used for intraocular masses as lesions are small, have an inhomogeneous T₁ and the eye is prone to motion. The aim of this paper is to address these eye-specific challenges, enabling accurate ocular DCE-MRI.

Materials & methods

DCE-MRI of 19 uveal melanoma (UM) patients was acquired using a fat-suppressed 3D spoiled gradient echo sequence with TWIST (time-resolved angiography with stochastic trajectories sequence). The analysis consisted of a two-step registration method to correct for both head and eye motion. A T₁ map was calculated to convert signal intensities to concentrations. Subsequently, the Tofts model was fitted voxel wise to obtain K^trans and v_e.

SUBMITTER: Jaarsma-Coes MG 

PROVIDER: S-EPMC8995252 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature