Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts.

ABSTRACT:

Background

Allergen-specific IL-4⁺ and IL-13⁺ CD4⁺ cells (type 2 cells) are essential for helping B cells to class-switch to IgE and establishing an allergic milieu in the gastrointestinal tract. The role of T cells in established food allergy is less clear.

Objective

We examined the food allergen-specific T-cell response in participants of 2 food allergen immunotherapy trials to assess the relationship of the T-cell response to clinical phenotypes, including response to immunotherapy.

Methods

Blood was obtained from 84 participants with peanut allergy and 142 participants with egg allergy who underwent double-blind placebo-controlled food challenges. Peanut- and egg-responsive T cells were identified by CD154 upregulation after stimul

SUBMITTER: Berin MC 

PROVIDER: S-EPMC8995337 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature