High RAD51 gene expression is associated with aggressive biology and with poor survival in breast cancer.

ABSTRACT:

Purpose

Although the DNA repair mechanism is important in preventing carcinogenesis, its activation in established cancer cells may support their proliferation and aggravate cancer progression. RAD51 cooperates with BRCA2 and is essential in the homologous recombination of DNA repair. To this end, we hypothesized that RAD51 gene expression is associated with cancer cell proliferation and poor prognosis of breast cancer (BC) patients.

Methods

A total of 8515 primary BC patients with transcriptome and clinical data from 17 independent cohorts were analyzed. The median value was used to divide each cohort into high and low RAD51 expression groups.

Results

High RAD51 expression enriched the DNA repair gene set and was correlated with DNA repair-related genes. Nottingham h

SUBMITTER: Wu R 

PROVIDER: S-EPMC8995390 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature