DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2.

ABSTRACT:

Background

The continued spread of SARS-CoV-2 and emergence of new variants with higher transmission rates and/or partial resistance to vaccines has further highlighted the need for large-scale testing and genomic surveillance. However, current diagnostic testing (e.g., PCR) and genomic surveillance methods (e.g., whole genome sequencing) are performed separately, thus limiting the detection and tracing of SARS-CoV-2 and emerging variants.

Results

Here, we developed DeepSARS, a high-throughput platform for simultaneous diagnostic detection and genomic surveillance of SARS-CoV-2 by the integration of molecular barcoding, targeted deep sequencing, and computational phylogenetics. DeepSARS enables highly sensitive viral detection, while also capturing genomic diversity and vira

SUBMITTER: Yermanos A 

PROVIDER: S-EPMC8995413 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature