CD93 in macrophages: A novel target for atherosclerotic plaque imaging?

ABSTRACT: Noninvasive imaging atherosclerotic (AS) plaque is of great importance for early diagnosis. Recently, CD93 in MΦ was linked to atherosclerosis development. Herein, we have investigated whether CD93 in MΦ is a potential novel target for atherosclerotic plaque imaging. CD93^hi and CD93^lo MΦ were prepared with or without LPS stimulation, before biological activity was evaluated. A rat AS model was produced with left carotid artery clamped. Whole-body/ex vivo phosphor autoradiography of the artery and biodistribution were investigated after incorporation of ³ H-2-DG into CD93^hi and CD93^lo MΦ or after ¹²⁵ I-α-CD93 (¹²⁵ I-anti-CD93mAb) injection. The plaque tissue was subjected to CD93/CD68 immunofluorescence/immunohisto

SUBMITTER: Su C 

PROVIDER: S-EPMC8995462 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature