Association between sleep disordered breathing in early pregnancy and glucose metabolism.

ABSTRACT:

Study objectives

To examine the association between maternal sleep disordered breathing (SDB) and glucose metabolism in early gestation.

Methods

Women with body mass index (BMI) ≥27 kg/m2 and singleton pregnancies underwent in-home sleep study (HSAT) and homeostatic model assessment (HOMA) in early pregnancy. Insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were derived. Exclusion criteria included pregestational diabetes, use of continuous positive airway pressure and chronic steroid therapy. We performed linear regression analyses to evaluate the association between continuous measures of SDB (respiratory event index (REI), and oxygen desaturation index (ODI)) and glucose metabolism parameters (HOMA-IR and HOMA %B). Analyses were adjusted for a set of a priori se

SUBMITTER: Sanapo L 

PROVIDER: S-EPMC8996028 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature