Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial.

ABSTRACT:

Introduction

Incidence of delirium after cardiac surgery remains high and delirium has a significant burden on short-term and long-term outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them. Preserving the circadian rhythm with overnight infusion of low-dose dexmedetomidine has been shown to lower the occurrence of delirium in older patients after non-cardiac surgery. However, these results remain controversial. The aim of this study was to demonstrate the usefulness of sleep induction by overnight infusion of dexmedetomidine to prevent delirium after cardiac surgery.

Methods and analysis

Dexmedetomidine after Cardiac Surgery for Prevention of Delirium is an investigator-initiated, randomised, placeb

SUBMITTER: Gargadennec T 

PROVIDER: S-EPMC8996049 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature