New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis.

ABSTRACT:

Background

A better understanding of the tumor immune microenvironment (TIME) will facilitate the development of prognostic biomarkers and more effective therapeutic strategies in patients with lung cancer. However, little has been reported on the comprehensive evaluation of complex interactions among cancer cells, immune cells, and local immunosuppressive elements in the TIME.

Methods

Whole-exome sequencing and RNA sequencing were carried out on 113 lung cancers. We performed single sample gene set enrichment analysis on TIME-related gene sets to develop a new scoring system (TIME score), consisting of T-score (tumor proliferation), I-score (antitumor immunity) and S-score (immunosuppression). Lung cancers were classified according to a combination of h

SUBMITTER: Shinohara S 

PROVIDER: S-EPMC8996063 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature