Effect of Autoinducer-2 Quorum Sensing Inhibitor on Interspecies Quorum Sensing.

ABSTRACT: Bacterial drug resistance caused by overuse and misuse of antibiotics is common, especially in clinical multispecies infections. It is of great significance to discover novel agents to treat clinical bacterial infections. Studies have demonstrated that autoinducer-2 (AI-2), a signal molecule in quorum sensing (QS), plays an important role in communication among multiple bacterial species and bacterial drug-resistance. Previously, 14 AI-2 inhibited compounds were selected through virtual screening by using the AI-2 receptor protein LuxP as a target. Here, we used Vibrio harveyi BB170 as a reporter strain for the preliminary screening of 14 inhibitors and compound Str7410 had higher AI-2 QS inhibition activity (IC₅₀ = 0.3724 ± 0.1091 μM). Then, co-culture of Pseudomonas

SUBMITTER: Jiang K 

PROVIDER: S-EPMC8996156 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature