Characterizing multiscale modular structures in medication-free obsessive-compulsive disorder patients with no comorbidity.

ABSTRACT: Brain networks exhibit signatures of modular structure, which maintains a fine trade-off between wiring cost and efficiency of information transmission. Alterations in modular structure have been found in patients with obsessive-compulsive disorder (OCD). However, previous studies were focused on a single scale (i.e., modularity or intra/intermodular connectivity) for investigation. Here, we recruited 92 OCD patients and 90 healthy controls. A comprehensive analysis was performed on modular architecture alterations in the voxelwise functional connectome at the "global" (modularity), "meso" (modular segregation and within- and between-module connections), and "local" (participation coefficients, PC) scales. We also examined the correlation between modular structure metrics and clinical symp

SUBMITTER: Li X 

PROVIDER: S-EPMC8996347 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature