Tracer-specific reference tissues selection improves detection of ¹⁸ F-FDG, ¹⁸ F-florbetapir, and ¹⁸ F-flortaucipir PET SUVR changes in Alzheimer's disease.

ABSTRACT: This study sought to identify a reference tissue-based quantification approach for improving the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies. A total of 794, 906, and 903 scans were included for ¹⁸ F-FDG, ¹⁸ F-florbetapir, and ¹⁸ F-flortaucipir, respectively. Positron emission tomography (PET) and T1-weighted images of participants were collected from the Alzheimer's disease Neuroimaging Initiative database, followed by partial volume correction. The standardized uptake value ratios (SUVRs) calculated from the cerebellum gray matter, centrum semiovale, and pons were evaluated at both region of interest (ROI) and voxelwise levels. The statistical power of reference tissues in

SUBMITTER: Li Y 

PROVIDER: S-EPMC8996354 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature