Combined experimental and computational study of Al₂O₃ catalyzed transamidation of secondary amides with amines.

ABSTRACT: Amides are the most extensively used substances in both synthetic organic and bioorganic chemistry. Unfortunately, the traditional synthesis of amides suffers from some important drawbacks, including low atom efficiency, high catalyst loading, separation of products from the reaction mixture and production of byproducts. Al₂O₃ is an amphoteric catalyst that activates the carbonyl carbon of the secondary amide group and helps the C-N cleavage of the reactant amide group by attacking the N-H hydrogen. By using the concepts of amphoteric properties of Al₂O₃, amides were synthesized from secondary amides and amines in the presence of triethylamine solvent. Several aliphatic and aromatic amines were used for the transamidation of N-methylbenzam

SUBMITTER: Ali MA 

PROVIDER: S-EPMC8996366 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature