Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background.

ABSTRACT:

Introduction

CD44 is a candidate gene for obesity and diabetes development and may be a critical mediator of a systemic inflammation associated with obesity and diabetes.

Methods

We investigated the relationship of CD44 with obesity in CD44-deficient mice challenged with a high-fat diet.

Results

In mice fed a diet high in fat, cholesterol, and sucrose for 12 weeks fat mass accumulation was reduced in CD44-deficient mice bred onto both a C57BL/6J and the naturally TLR deficient C3H/HeJ background. Reduced fat mass could not be attributed to lower food intake or an increase in energy expenditure as measured by indirect calorimetry. However, we observed a 40-60% lower mRNA expression of the inflammation markers, F4/80, CD11b, TNF-α, and CD14, in adipose tissue of CD44-de

SUBMITTER: VerHague M 

PROVIDER: S-EPMC8996418 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature