Ontology highlight
ABSTRACT:
SUBMITTER: Argueta LB
PROVIDER: S-EPMC8996470 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Argueta Lissenya B LB Lacko Lauretta A LA Bram Yaron Y Tada Takuya T Carrau Lucia L Rendeiro André Figueiredo AF Zhang Tuo T Uhl Skyler S Lubor Brienne C BC Chandar Vasuretha V Gil Cristianel C Zhang Wei W Dodson Brittany J BJ Bastiaans Jeroen J Prabhu Malavika M Houghton Sean S Redmond David D Salvatore Christine M CM Yang Yawei J YJ Elemento Olivier O Baergen Rebecca N RN tenOever Benjamin R BR Landau Nathaniel R NR Chen Shuibing S Schwartz Robert E RE Stuhlmann Heidi H
iScience 20220411 5
The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two mothers with symptomatic COVID-19 whose pregnancies resulted in adverse outcomes for the fetuses contained high levels of viral Alpha variant RNA. The RNA was localized to the trophoblasts that cover the fetal chorionic villi in direct contact with maternal blood ...[more]