High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains.

ABSTRACT:

Background

The structural connectivity of neurons in the brain allows active neurons to impact the physiology of target neuron types with which they are functionally connected. While the structural connectome is at the basis of functional connectome, it is the functional connectivity measured through correlations between time series of individual neurophysiological events that underlies behavioral and mental states. However, in light of the diverse neuronal cell types populating the brain and their unique connectivity properties, both neuronal activity and functional connectivity are heterogeneous across the brain, and the nature of their relationship is not clear. Here, we employ brain-wide calcium imaging at cellular resolution in larval zebrafish to understand the principles of

SUBMITTER: Zarei M 

PROVIDER: S-EPMC8996543 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature