Estimation of treatment effects in observational stroke care data: comparison of statistical approaches.

ABSTRACT:

Introduction

Various statistical approaches can be used to deal with unmeasured confounding when estimating treatment effects in observational studies, each with its own pros and cons. This study aimed to compare treatment effects as estimated by different statistical approaches for two interventions in observational stroke care data.

Patients and methods

We used prospectively collected data from the MR CLEAN registry including all patients (n = 3279) with ischemic stroke who underwent endovascular treatment (EVT) from 2014 to 2017 in 17 Dutch hospitals. Treatment effects of two interventions - i.e., receiving an intravenous thrombolytic (IVT) and undergoing general anesthesia (GA) before EVT - on good functional outcome (modified Rankin Scale ≤2) were estimated. We used thr

SUBMITTER: Amini M 

PROVIDER: S-EPMC8996562 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature