α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

ABSTRACT:

Background

Patients with Parkinson's disease (PD) show motor symptoms as well as various non-motor symptoms. Postmortem studies of PD have suggested that initial alpha-synuclein (α-Syn) pathology develops independently in the olfactory bulb and lower brainstem, spreading from there stereotypically. However, it remains unclear how these two pathological pathways contribute to the clinicopathological progression of PD.

Objective

The objective of this study was to examine the clinicopathological contribution of α-Syn spread from the olfactory bulb.

Methods

We conducted pathological and behavioral analyses of human α-Syn bacterial artificial chromosome transgenic mice injected with α-Syn preformed fibrils into the bilateral olfactory bulb up to 10 months postinjection.

SUBMITTER: Uemura N 

PROVIDER: S-EPMC8996681 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature