The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults.

ABSTRACT: Previous studies have indicated that physical activity may be beneficial in reducing the risk for Alzheimer's disease (AD), although the underlying mechanisms are not fully understood. The goal of this study was to evaluate the relationship between habitual physical activity levels and brain amyloid deposition and AD-related blood biomarkers (i.e., measured using a novel high-performance mass spectrometry-based assay), in apolipoprotein E (APOE) ε4 carriers and noncarriers. We evaluated 143 cognitively normal older adults, all of whom had brain amyloid deposition assessed using positron emission tomography and had their physical activity levels measured using the International Physical Activity Questionnaire (IPAQ). We observed an inverse correlation between brain amyloidosis and pl

SUBMITTER: Pedrini S 

PROVIDER: S-EPMC8996810 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature