Ontology highlight
ABSTRACT:
SUBMITTER: Qiao S
PROVIDER: S-EPMC8996997 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Qiao Shiyao S Wang Wenmeng W Yi Cheng C Xu Qingqing Q Wang Wenfei W Shi Jinming J Stovall Daniel B DB Li Dangdang D Sui Guangchao G
Cancers 20220322 7
Yin Yang 1 (YY1) plays an oncogenic role through regulating the expression of various cancer-related genes and activating key oncoproteins. Previous research reported that YY1 protein formed dimers or oligomers without definite biological implications. In this study, we first demonstrated the oncoprotein binding (OPB) and zinc finger (ZF) domains of YY1 as the regions involved in its intermolecular interactions. ZFs are well-known for protein dimerization, so we focused on the OPB domain. After ...[more]