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Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13.

ABSTRACT: Three new sorbicillinoids, including trimer trisorbicillinone E (1), acremosorbicillinoids A and B (2 and 3), and a new alkaloid acremokaloid A (4), and a new natural product 2S,3S-acetyl-β-methyltryptophan (5), were isolated from an endophytic fungus Acremonium citrinum SS-g13, which is found in Fructus mori plant root. In addition, eight known sorbicillinoids (6-13) were also obtained. The new compound structures were established using NMR, HRESIMS spectra, and reported spectroscopic data. The absolute configurations of compounds 1-5, were determined by spectroscopic analysis, Snatzke's method, and time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. Compound 11 exhibited significant cholesterol efflux enhancing activity. A plausible biosynthesis pathway for the sorbicillinoids is discussed.

SUBMITTER: Peng XP

PROVIDER: S-EPMC8997241 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Structurally Various Sorbicillinoids From an Endophytic Fungus Acremonium citrinum SS-g13.

Peng Xiao-Ping XP Li Gang G Wang Li-Mei LM Wang Qi Q Wang Cong C Ji Li-Xia LX Cao Chen-Xi CX Lin Guo-Feng GF Jiang Zu-Yang ZY He Zhuo-Qian ZQ Wang Pei P Lou Hong-Xiang HX

Frontiers in microbiology 20220323

Three new sorbicillinoids, including trimer trisorbicillinone E (1), acremosorbicillinoids A and B (2 and 3), and a new alkaloid acremokaloid A (4), and a new natural product 2S,3S-acetyl-β-methyltryptophan (5), were isolated from an endophytic fungus Acremonium citrinum SS-g13, which is found in Fructus mori plant root. In addition, eight known sorbicillinoids (6-13) were also obtained. The new compound structures were establ ...[more]

PMID: 35418970

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