An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns.

ABSTRACT: More than 90% of genetic variants are rare in most modern sequencing studies, such as the Alzheimer's Disease Sequencing Project (ADSP) whole-exome sequencing (WES) data. Furthermore, 54% of the rare variants in ADSP WES are singletons. However, both single variant and unit-based tests are limited in their statistical power to detect an association between rare variants and phenotypes. To best use missense rare variants and investigate their biological effect, we examine their association with phenotypes in the context of protein structures. We developed a protein structure-based approach, protein optimized kernel evaluation of missense nucleotides (POKEMON), which evaluates rare missense variants based on their spatial distribution within a protein rather than their allele frequency. The

SUBMITTER: Jin B 

PROVIDER: S-EPMC8997344 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature