High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α.

ABSTRACT: The global burden of malaria and toxoplasmosis has been limited by the use of efficacious anti-parasitic agents, however, emerging resistance in Plasmodium species and Toxoplasma gondii threatens disease control worldwide, implying that new agents/therapeutic targets are urgently needed. Nuclear localization signal (NLS)-dependent transport into the nucleus, mediated by members of the importin (IMP) superfamily of nuclear transporters, has shown potential as a target for intervention to limit viral infection. Here, we show for the first time that IMPα from P. falciparum and T. gondii have promise as targets for small molecule inhibitors. We use high-throughput screening to identify agents able to inhibit P. falciparum IMPα binding to a P. falciparum

SUBMITTER: Walunj SB 

PROVIDER: S-EPMC8997399 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature