Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

ABSTRACT: Insulin-degrading enzyme (IDE) is a multifunctional protease due to the variety of its substrates, its various cellular locations, its conservation between species and its many non-proteolytic functions. Numerous studies have successfully demonstrated its implication in two main therapeutic areas: metabolic and neuronal diseases. In recent years, several reports have underlined the overexpression of this enzyme in different cancers. Still, the exact role of IDE in the physiopathology of cancer remains to be elucidated. Known as the main enzyme responsible for the degradation of insulin, an essential growth factor for healthy cells and cancer cells, IDE has also been shown to behave like a chaperone and interact with the proteasome. The pharmacological modulation of IDE (siRNA, chemical com

SUBMITTER: Lesire L 

PROVIDER: S-EPMC8998118 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature