The Landscape of Novel Expressed Chimeric RNAs in Rheumatoid Arthritis.

ABSTRACT: In cancers and other complex diseases, the fusion of two genes can lead to the production of chimeric RNAs, which are associated with disease development. Several recurrent chimeric RNAs are expressed in different cancers and are thus used for clinical cancer diagnosis. Rheumatoid arthritis (RA) is an immune-mediated joint disorder resulting in synovial inflammation and joint destruction. Despite advances in therapy, many patients do not respond to treatment and present persistent inflammation. Understanding the landscape of chimeric RNA expression in RA patients could provide a better insight into RA pathogenesis, which might provide better treatment strategies and tailored therapies. Accordingly, we analyzed the publicly available RNA-seq data of synovium tissue from 151 RA patients and

SUBMITTER: Detroja R 

PROVIDER: S-EPMC8998144 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature