Store-Operated Ca²⁺ Entry Contributes to Piezo1-Induced Ca²⁺ Increase in Human Endometrial Stem Cells.

ABSTRACT: Endometrial mesenchymal stem cells (eMSCs) are a specific class of stromal cells which have the capability to migrate, develop and differentiate into different types of cells such as adipocytes, osteocytes or chondrocytes. It is this unique plasticity that makes the eMSCs significant for cellular therapy and regenerative medicine. Stem cells choose their way of development by analyzing the extracellular and intracellular signals generated by a mechanical force from the microenvironment. Mechanosensitive channels are part of the cellular toolkit that feels the mechanical environment and can transduce mechanical stimuli to intracellular signaling pathways. Here, we identify previously recorded, mechanosensitive (MS), stretch-activated channels as Piezo1 proteins in the plasma membrane of eMS

SUBMITTER: Chubinskiy-Nadezhdin V 

PROVIDER: S-EPMC8998223 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature