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Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-a]pyrimidine Derivatives and Tetrahydrothiophene-1-Oxide or Diphenyl Sulfoxide.

ABSTRACT: The platinum(II) complexes of general formula [PtCl2(dstp)(S-donor)] were dstp 5,7-dimethyl-1,2,4-triazolo[1,5-a]-pyrimidine (dmtp), 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine (dbtp), 5-methyl-7-isobutyl-1,2,4-triazolo[1,5-a]pyrimidine (ibmtp) or 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), whereas S-tetrahydrothio-phene-1-oxide (TMSO) or diphenyl sulfoxide (DPSO) were synthesized in a one-pot reaction. Here, we present experimental data (1H, 13C, 15N, 195Pt NMR, IR, X-ray) combined with density functional theory (DFT) computations to support and characterize structure-spectra relationships and determine the geometry of dichloride platinum(II) complexes with selected triazolopyrimidines and sulfoxides. Based on the experimental and theoretical data, factors affecting the stability of platinum(II) complexes have been determined.

SUBMITTER: Jakubowski M 

PROVIDER: S-EPMC8998453 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidine Derivatives and Tetrahydrothiophene-1-Oxide or Diphenyl Sulfoxide.

Jakubowski Mateusz M   Łakomska Iwona I   Kaszuba Adriana A   Wojtczak Andrzej A   Sitkowski Jerzy J   Jarzęcki Andrzej A AA  

International journal of molecular sciences 20220326 7

The platinum(II) complexes of general formula [PtCl<sub>2</sub>(dstp)(S-donor)] were dstp 5,7-dimethyl-1,2,4-triazolo[1,5-<i>a</i>]-pyrimidine (dmtp), 5,7-ditertbutyl-1,2,4-triazolo[1,5-<i>a</i>]pyrimidine (dbtp), 5-methyl-7-isobutyl-1,2,4-triazolo[1,5-<i>a</i>]pyrimidine (ibmtp) or 5,7-diphenyl-1,2,4-triazolo[1,5-<i>a</i>]pyrimidine (dptp), whereas S-tetrahydrothio-phene-1-oxide (TMSO) or diphenyl sulfoxide (DPSO) were synthesized in a one-pot reaction. Here, we present experimental data (<sup>  ...[more]

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