Store-Operated Ca²⁺ Entry in Skeletal Muscle Contributes to the Increase in Body Temperature during Exertional Stress.

ABSTRACT: Exertional heat stroke (HS) is a hyperthermic crisis triggered by an excessive accumulation of Ca²⁺ in skeletal muscle fibers. We demonstrated that exercise leads to the formation of calcium entry units (CEUs), which are intracellular junctions that reduce muscle fatigue by promoting the recovery of extracellular Ca²⁺ via store-operated Ca²⁺ entry (SOCE). Here, we tested the hypothesis that exercise-induced assembly of CEUs may increase the risk of HS when physical activity is performed in adverse environmental conditions (high temperature and humidity). Adult mice were: (a) first, divided into three experimental groups: control, trained-1 month (voluntary running in wheel cages), and acutely exercised-1 h (incremental treadmill run); and (b) then subjected

SUBMITTER: Girolami B 

PROVIDER: S-EPMC8998704 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature