Investigating the Potential Use of Chemical Biopsy Devices to Characterize Brain Tumor Lipidomes.

ABSTRACT: The development of a fast and accurate intraoperative method that enables the differentiation and stratification of cancerous lesions is still a challenging problem in laboratory medicine. Therefore, it is important to find and optimize a simple and effective analytical method of enabling the selection of distinctive metabolites. This study aims to assess the usefulness of solid-phase microextraction (SPME) probes as a sampling method for the lipidomic analysis of brain tumors. To this end, SPME was applied to sample brain tumors immediately after excision, followed by lipidomic analysis via liquid chromatography-high resolution mass spectrometry (LC-HRMS). The results showed that long fibers were a good option for extracting analytes from an entire lesion to obtain an average lipidomic pr

SUBMITTER: Bogusiewicz J 

PROVIDER: S-EPMC8998862 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature