COMMD10 is critical for Kupffer cell survival and controls Ly6C^hi monocyte differentiation and inflammation in the injured liver.

ABSTRACT: Liver-resident macrophages Kupffer cells (KCs) and infiltrating Ly6C^hi monocytes both contribute to liver tissue regeneration in various pathologies but also to disease progression upon disruption of orderly consecutive regeneration cascades. Little is known about molecular pathways that regulate their differentiation, maintenance, or inflammatory behavior during injury. Here, we show that copper metabolism MURR1 domain (COMMD)10-deficient KCs adopt liver-specific identity. Strikingly, COMMD10 deficiency in KCs and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6C^hi monocytes. While COMMD10 deficiency in KCs mildly worsens acetaminophen-induced liver injury (AILI), its deficiency in Ly6C^hi

SUBMITTER: Cohen K 

PROVIDER: S-EPMC8998879 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature