Application of the MAHDS Method for Multiple Alignment of Highly Diverged Amino Acid Sequences.

ABSTRACT: The aim of this work was to compare the multiple alignment methods MAHDS, T-Coffee, MUSCLE, Clustal Omega, Kalign, MAFFT, and PRANK in their ability to align highly divergent amino acid sequences. To accomplish this, we created test amino acid sequences with an average number of substitutions per amino acid (x) from 0.6 to 5.6, a total of 81 sets. Comparison of the performance of sequence alignments constructed by MAHDS and previously developed algorithms using the CS and Z score criteria and the benchmark alignment database (BAliBASE) indicated that, although the quality of the alignments built with MAHDS was somewhat lower than that of the other algorithms, it was compensated by greater statistical significance. MAHDS could construct statistically significant alignments of artificial seq

SUBMITTER: Kostenko DO 

PROVIDER: S-EPMC8998981 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature