The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer.

ABSTRACT: Post-translational modifications of proteins ensure optimized cellular processes, including proteostasis, regulated signaling, cell survival, and stress adaptation to maintain a balanced homeostatic state. Abnormal post-translational modifications are associated with cellular dysfunction and the occurrence of life-threatening diseases, such as cancer and neurodegenerative diseases. Therefore, some of the frequently seen protein modifications have been used as disease markers, while others are targeted for developing specific therapies. The ubiquitin and ubiquitin-like post-translational modifiers, namely, small ubiquitin-like modifier (SUMO) and neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8), share several features, such as protein structures, enzymatic

SUBMITTER: Pellegrino NE 

PROVIDER: S-EPMC8999128 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature