Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review.

ABSTRACT: Autophagy is a complex process involved in several cell activities, including tissue growth, differentiation, metabolic modulation, and cancer development. In prostate cancer, autophagy has a pivotal role in the regulation of apoptosis and disease progression. Several molecular pathways are involved, including PI3K/AKT/mTOR. However, depending on the cellular context, autophagy may play either a detrimental or a protective role in prostate cancer. For this purpose, current evidence has investigated how autophagy interacts within these complex interactions. In this article, we discuss novel findings about autophagic machinery in order to better understand the therapeutic response and the chemotherapy resistance of prostate cancer. Autophagic-modulation drugs have been employed in clinical t

SUBMITTER: Loizzo D 

PROVIDER: S-EPMC8999129 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature