The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis: A Global Study.

ABSTRACT:

Introduction

Several scoring systems predict mortality in alcohol-associated hepatitis (AH), including the Maddrey discriminant function (mDF) and model for end-stage liver disease (MELD) score developed in the United States, Glasgow alcoholic hepatitis score in the United Kingdom, and age, bilirubin, international normalized ratio, and creatinine score in Spain. To date, no global studies have examined the utility of these scores, nor has the MELD-sodium been evaluated for outcome prediction in AH. In this study, we assessed the accuracy of different scores to predict short-term mortality in AH and investigated additional factors to improve mortality prediction.

Methods

Patients admitted to hospital with a definite or probable AH were recruited by 85 tertiary centers in 11

SUBMITTER: Morales-Arraez D 

PROVIDER: S-EPMC8999152 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature