Sensing the Messenger: Potential Roles of Cyclic-di-GMP in Rickettsial Pathogenesis.

ABSTRACT: Pathogenic bacteria causing human rickettsioses, transmitted in nature by arthropod vectors, primarily infect vascular endothelial cells lining the blood vessels, resulting in 'endothelial activation' and onset of innate immune responses. Nucleotide second messengers are long presumed to be the stimulators of type I interferons, of which bacterial cyclic-di-GMP (c-di-GMP) has been implicated in multiple signaling pathways governing communication with other bacteria and host cells, yet its importance in the context of rickettsial interactions with the host has not been investigated. Here, we report that all rickettsial genomes encode a putative diguanylate cyclase pleD, responsible for the synthesis of c-di-GMP. In silico analysis suggests that although the domain architecture of Ple

SUBMITTER: Narra HP 

PROVIDER: S-EPMC8999164 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature