Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation.

ABSTRACT: The angiotensin II (Ang II) type 1 receptor (AT₁R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist). AT₁R can also be activated by auto-antibodies (AT₁R-Abs), which are associated with manifold diseases, such as obliterative vasculopathy, preeclampsia and systemic sclerosis. Knowledge of the molecular mechanisms related to AT₁R-Abs binding and associated signaling cascade (dys-)regulation remains fragmentary. The goal of this study was, therefore, to investigate details of the effects of AT₁R-Abs on G-protein signaling and subsequent cell proliferation, as well as the putative contribution of the three extracellular receptor lo

SUBMITTER: Philippe A 

PROVIDER: S-EPMC8999261 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature