Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC9000248 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Wang Jinan J Bhattarai Apurba A Do Hung N HN Akhter Sana S Miao Yinglong Y
Molecules (Basel, Switzerland) 20220322 7
G protein-coupled receptors (GPCRs) represent the largest family of human membrane proteins. Four subtypes of adenosine receptors (ARs), the A<sub>1</sub>AR, A<sub>2A</sub>AR, A<sub>2B</sub>AR and A<sub>3</sub>AR, each with a unique pharmacological profile and distribution within the tissues in the human body, mediate many physiological functions and serve as critical drug targets for treating numerous human diseases including cancer, neuropathic pain, cardiac ischemia, stroke and diabetes. The ...[more]