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Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT_1A) Receptors Heterodimerization and Cellular Effectors (Ca²⁺, ERK1/2 and p38) Activation.

ABSTRACT: The importance of the dynamic interplay between the opioid and the serotonin neuromodulatory systems in chronic pain is well recognized. In this study, we investigated whether these two signalling pathways can be integrated at the single-cell level via direct interactions between the mu-opioid (MOP) and the serotonin 1A (5-HT_1A) receptors. Using fluorescence cross-correlation spectroscopy (FCCS), a quantitative method with single-molecule sensitivity, we characterized in live cells MOP and 5-HT_1A interactions and the effects of prolonged (18 h) exposure to selected non-peptide opioids: morphine, codeine, oxycodone and fentanyl, on the extent of these interactions. The results indicate that in the plasma membrane, MOP and 5-HT_1A receptors form heterodimers t

SUBMITTER: Radoi V

PROVIDER: S-EPMC9000251 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT_1A) Receptors Heterodimerization and Cellular Effectors (Ca²⁺, ERK1/2 and p38) Activation.

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Dataset Information

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT_1A) Receptors Heterodimerization and Cellular Effectors (Ca²⁺, ERK1/2 and p38) Activation.