Synthesis of Novel C/D Ring Modified Bile Acids.

ABSTRACT: Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure-activity relationships and define compounds that activate these receptors selectively. Towards this, access to large quantities of a chenodeoxycholic acid derivative bearing a C-12 methyl and a C-13 to C-14 double bond provided an interesting scaffold to investigate the chemical manipulation of the C/D ring junction in bile acids. The reactivity of this alkene substrate with various zinc carbenoid species showed that those generated using the Furukawa methodology achieved selective α-cyclopropanation, whereas those generated using the Shi methodology reacted in an une

SUBMITTER: Landaeta Aponte RA 

PROVIDER: S-EPMC9000252 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature