Ruthenium Photosensitizers for NIR PDT Require Lowest-Lying Triplet Intraligand (³IL) Excited States.

ABSTRACT: A family of complexes of the type [Ru(tpbn)(IP-R)(4-pic)]Cl₂ (tbpn=2,2'-(4-(tert-butyl)pyridine-2,6-diyl)bis(1,8-napthyridine); 4-pic=4-picoline; IP-R=imidazo[4,5-f][1,10]phenanthroline attached to an aromatic group R for 2-8 and H for 1) were prepared as near-infrared (NIR) absorbing coordination complexes to test whether triplet intraligand excited states (³IL) of higher energy than the lowest-lying triplet metal-to-ligand charge transfer excited states (³MLCT) could effectively generate cytotoxic singlet oxygen (¹O₂) and elicit in vitro photodynamic therapy (PDT) effects. Aromatic groups ranged from benzene to anthracene, with corresponding triplet state energies that were all significantly higher

SUBMITTER: Lifshits LM 

PROVIDER: S-EPMC9000368 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature