Volumetric Scalability of Microfluidic and Semi-Batch Silk Nanoprecipitation Methods.

ABSTRACT: Silk fibroin nanoprecipitation by organic desolvation in semi-batch and microfluidic formats provides promising bottom-up routes for manufacturing narrow polydispersity, spherical silk nanoparticles. The translation of silk nanoparticle production to pilot, clinical, and industrial scales can be aided through insight into the property drifts incited by nanoprecipitation scale-up and the identification of critical process parameters to maintain throughout scaling. Here, we report the reproducibility of silk nanoprecipitation on volumetric scale-up in low-shear, semi-batch systems and estimate the reproducibility of chip parallelization for volumetric scale-up in a high shear, staggered herringbone micromixer. We showed that silk precursor feeds processed in an unstirred semi-batch system (m

SUBMITTER: Matthew SAL 

PROVIDER: S-EPMC9000471 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature