The Impact of BCL11A Polymorphisms on Endometrial Cancer Risk Among Chinese Han Females.

ABSTRACT:

Background

Endometrial carcinoma (EC) is one of the most common malignant gynecological malignancies. BCL11A gene may have a tumor-suppressor role in EC. Until now, no studies have reported the effect of BCL11A variants on EC predisposition in Chinese population.

Methods

Six BCL11A polymorphisms were genotyped using Agena MassARRAY system among 509 EC patients and 506 matched healthy women. Risk assessment of the BCL11A polymorphisms for EC risk was performed by calculating odds ratios (OR) with 95% confidence intervals (CI) through logistic regression models.

Results

We found that rs7581162 (OR = 1.29, p = 0.012), rs10189857 (OR = 1.26, p = 0.028), rs1427407 (OR = 1.30, p = 0.015), rs766432 (OR = 1.27, p = 0.025

SUBMITTER: Cai J 

PROVIDER: S-EPMC9000540 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature