Dataset Information
Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure-Activity Relationships for Vitiligo.
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ABSTRACT:
SUBMITTER: Song JW
PROVIDER: S-EPMC9000856 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Isolation of a Melanoblast Stimulator from <i>Dimocarpus longan</i>, Its Structural Modification, and Structure-Activity Relationships for Vitiligo.
Molecules (Basel, Switzerland) 20220325 7
A novel melanoblast stimulator (<b>1</b>) was isolated from <i>Dimocarpus longan</i>. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, <b>1</b>) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (<b>1</b>) was discovered here for the first time. Both HMF and its synthetic analog (<b>16</b>) promote the differentiation and migration of melanoblas ...[more]
