Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.

ABSTRACT: HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antib

SUBMITTER: Molinos-Albert LM 

PROVIDER: S-EPMC9001681 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature