NAMPT-dependent NAD⁺ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress.

ABSTRACT: Oxidative stress is a state in which the accumulation of reactive oxygen species exceeds the capacity of cellular antioxidant systems. Both apoptosis and necrosis are observed under oxidative stress, and we have reported that these two forms of cell death are induced in H₂O₂-stimulated HeLa cells depending on the concentration of H₂O₂. Weak H₂O₂ stimulation induces apoptosis, while strong H₂O₂ stimulation induces necrosis. However, the detailed mechanisms controlling the switching between these forms of cell death depending on the level of oxidative stress remain elusive. Here, we found that NAD⁺ metabolism is a key factor in determining the form of cell death in H₂O₂-st

SUBMITTER: Nishida T 

PROVIDER: S-EPMC9001718 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature